文献类型：期刊文献

英文题名：Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria

作者：Meng, Qingpeng[1];Xiao, Ciying[1];Wang, Zejian[1];Shang, Yazhuo[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2025

卷号：12

期号：1

外文期刊名：COSMETICS

收录：WOS:【ESCI(收录号:WOS:001429527000001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 22308094), the Independent Research Fund of the Yunnan Characteristic Plant Extraction Laboratory (2022YKZY004), the Fundamental Research Funds for the Central Universities (2022ZFJH004 and 222201717003), and the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002).

语种：英文

外文关键词：probiotics; skin microbiome; Malassezia furfur; Propionibacterium acnes; antibacterial; metabolites

摘要：The topical application of probiotic metabolites has shown positive effects in the treatment of skin diseases; however, the effectiveness is strain dependent. Comparing the pathogen inhibitory effects of probiotic strains with different genetic backgrounds and analyzing their key metabolites can provide insights about the potential of applying probiotics for skincare. In this study, we investigated the fermentation growth inhibition of 18 commercial probiotic strains on the skin pathogens Malassezia furfur (M. furfur) and Cutibacterium acnes (C. acnes) in vitro. We found that most Bifidobacterium animalis subsp. lactis (B. lactis) and Lacticaseibacillus rhamnosus (L. rhamnosus) strains exhibited strong inhibition of M. furfur and C. acnes, which lasted up to 100 h. The main antibacterial metabolites observed were molecules below 10,000 Da in molecular weight, including peptides and organic acids (lactic acid, acetic acid, propionic acid, and butyric acid). The synergistic effect of organic acid combinations lowered the minimum inhibitory concentration (MIC). The composition of these antimicrobial metabolites varied among strains, which demonstrated the strain-dependent pathogenic inhibitory effects. This study provides insights into the application potential of using probiotic metabolites against seborrheic dermatitis and acne-related pathogenic bacteria.