文献类型：期刊文献

英文题名：Fabrication of resveratrol-loaded zein nanoparticles based on flash nanoprecipitation

作者：Xing, Mengyuan[1,2];Zhao, Hongyang[1,2];Ahmed, Rizwan[1,2];Wang, Xinming[1,2];Liu, Jinbo[1,2];Wang, Junyou[1,2];Guo, Aijun[3];Wang, Mingwei[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Maternal & Child Hlth Care Hosp Yuzhou, Dept Internal Med, Yuzhou 461670, Henan, Peoples R China

年份：2022

卷号：654

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20223912811325);WOS:【SCI-EXPANDED(收录号:WOS:000859970900005)】；

基金：This work was supported by "1000 Foreign Experts Program" (WQ20163100341), and National Natural Science Foundation of China (NSFC) for Young Scholars (21706074).

语种：英文

外文关键词：Resveratrol; Zein nanoparticles; Flash nanoprecipitation; Controlled fabrication; Regulated properties

摘要：Resveratrol (Res) has drawn great interests due to its potential benefits on human health, while applications of Res in nutritional and pharmaceutical fields are limited due to its poor water solubility, low bioavailability and instability. Here in this work, an advanced anti-solvent precipitation strategy, flash nanoprecipitation (FNP), has been applied for controlled fabrication of Res-loaded nanoparticles (NPs). Specifically, solvent streams containing Res and zein (stabilizing polymers) blend with anti-solvent streams in a multi-inlet vortex mixer (MIVM), which enables fast mixing on the order of millisecond and creates kinetically trapped NPs. The efficient fabrication and effects of different control factors on the particle formation and properties have been fully explored by means of static and dynamic light scattering, TEM, fourier-transform infrared and fluorescence. The obtained NPs exhibit tunable sizes from 50 to 108 nm with narrow size distribution (PDI -0.1), enhanced drug loading content (30-57 %), improved stability and antioxidant capacity. These satisfied properties are assigned to the kinetic control of FNP, our study therefore develops a facile and alternative fabrication strategy for controlled preparation of Res-loaded NPs.