文献类型：期刊文献

英文题名：Novel synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via a one-pot three-component reaction of boronic acids, azide, and active methylene ketones

作者：Zhang, Jian[1];Jin, Guanyi[1];Xiao, Senhan[1];Wu, Jingjing[1];Cao, Song[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2013

卷号：69

期号：10

起止页码：2352

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000315321500016)，CCR-EXPANDED(收录号:WOS:000315321500016)】；

基金：We are grateful for financial supports from the National Natural Science Foundation of China (Grant No. 21072057, 21272070), the Key Project in the National Science & Technology Pillar Program of China in the twelfth five-year plan period (2011BAE06B01-15), the National Basic Research Program of China (973 Program, 2010CB126101), and the National High Technology Research and Development Program of China (863 Program, 2011AA10A204).

语种：英文

外文关键词：Boronic acids; Azides; Multicomponent reactions; Cyclization; 1,4,5-Trisubstituted 1,2,3-triazoles

摘要：A series of 1-aryl-5-trifluoromethyl (or difluoromethyl)-1,4,5-trisubstituted 1,2,3-triazoles were synthesized in high yield by a novel one-pot three-component reaction of arylboronic acids, sodium azide, and active methylene ketones, such as ethyl 4,4-difluoroacetoacetate or ethyl 4,4,4-trifluoroacetoacetate in the presence of Cu(OAc)(2) and piperidine using a DMSO/H2O (10/1) mixture as solvent. (C) 2013 Elsevier Ltd. All rights reserved.