文献类型：期刊文献

英文题名：Enantioselective Construction of Spirooxindole Derivatives: Asymmetric [3+2] Cyclization of Isothiocyanatooxindoles with Allenic Esters or 2-Butynedioic Acid Diesters

作者：Du, Dan[1,2];Jiang, Yu[1,2];Xu, Qin[3];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：355

期号：11-12

起止页码：2249

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000327799600021)，CCR-EXPANDED(收录号:WOS:000327799600021)】；

基金：We thank the Shanghai Municipal Committee of Science and Technology (11JC1402600), the National Basic Research Program of China (973)-2010CB833302, and the National Natural Science Foundation of China for financial support (21072206, 21102166, 20472096, 20872162, 20672127, 21121062 and 20732008).

语种：英文

外文关键词：allenic esters; asymmetric [3+2] cycloaddition; Cinchona alkaloids; organocatalysts; spirooxindole derivatives

摘要：A novel Cinchona alkaloid-derived organocatalyst having stronger hydrogen-bonding donors that catalyzes the asymmetric [3+2] cycloaddition of 3-isothiocyanatooxindoles with allenic esters or 2-butynedioic acid diesters has been developed, affording functionalized spirooxindole derivatives in high yields along with good to excellent enantioselectivities under mild conditions. We also found that by changing the ratio of the substrates, different spirooxindole derivatives could be obtained in high yields along with good to excellent enantioselectivities.