文献类型：期刊文献

英文题名：Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity

作者：Xuan, Qize[1];He, Jiaxin[1];Li, Min[2];Chai, Ruoshi[1];Wang, Chenxuan[3];Wang, Yibing[1];Wang, Ping[4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Collaborat Innovat Ctr Biomfg Technol, Sch Biotechnol,Biomed Nanotechnol Ctr, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 19B Yuquan Rd, Beijing 100049, Shijingshan Dis, Peoples R China;[3]Chinese Acad Med Sci, Peking Union Med Coll, Dept Biophys & Struct Biol, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China;[4]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

年份：2020

卷号：56

期号：11

起止页码：1633

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20200708169545);WOS:【SCI-EXPANDED(收录号:WOS:000513177300031)】；

基金：This work was sponsored by the Natural Science Foundation of Shanghai (19ZR1412400), CAMS Innovation Fund for Medical Sciences (CIFMS 2018-I2M-3-006), the Fundamental Research Funds for the Central Universities (2018PT31028), the Open Project Fund provided by Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS (NSKF201812), and the National Natural Science Foundation of China (21636003 and 31901007).

语种：英文

外文关键词：Peptides

摘要：We utilized solution-phase biopanning to obtain a de novo peptide (LA12) that specifically bound to the core region of the human amylin monomer. LA12 stabilized the random coil conformation of amylin to suppress aggregation in a dose-dependent manner with the highest suppression effect of 78% and reduced the cytotoxicity of amylin.