文献类型：期刊文献

中文题名：流化床侧喷技术制备乳糖颗粒的工艺

英文题名：Preparation of Lactose Particles Using Side Spray Technology in a Fluidized Bed

作者：宗瑞霞[1];景秋芳[1];马小思[1];任福正[1]

机构：[1]华东理工大学药学院,上海市新药设计重点实验室,上海200237

年份：2012

卷号：12

期号：5

起止页码：760

中文期刊名：过程工程学报

外文期刊名：The Chinese Journal of Process Engineering

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2011_2012】；

基金：国家"重大新药创制"科技重大专项基金资助项目(编号:2011ZX09102-005-02);上海市科委重点实验室资助项目(编号:11DZ2260600)

语种：中文

中文关键词：流化床;侧喷技术;乳糖;制粒;工艺参数

外文关键词：fluidized bed; side spray; lactose; granulation; process parameter

摘要：采用流化床侧喷制粒技术,以羟丙基甲基纤维素K4M为粘合剂制备乳糖颗粒.以颗粒粒径分布与流动性为主要评价指标,得到优化的制备参数为:粘合剂浓度1.5%,用量2.0%,喷液速度14～18g/min,雾化压力1.5×105Pa.200～355μm的目标粒子收率在85%以上,颗粒休止角均小于34°压缩度均小于10%,流动性好,光学显微镜下颗粒呈类球形.制备工艺稳定,重现性好.
Preparation of lactose particles in a fluidized bed was investigated using side spray technology. The particle size distribution and flowability were selected to evaluate the granulation with hydroxypropyl methylcellulose K4M as binding agent. Over 85%（φ） of the particles were in the range of 200-355 μm when optimum formulation and process parameters were chosen, including the concentration of binding agent 1.5%（ω）, its mass increment 2%, spray rate 14-18 g/min, and atomization pressure 1.5×10^5 Pa. The slope of repose of granules （〈34°） and degree of compression （〈10%） showed the good flowability of lactose particles. The particles had a spherical shape, when observed under an optical microscope. The preparation process was very stable and had a good repeatability,