文献类型：期刊文献

英文题名：Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

作者：Cao, Huiliang[1,2,3];Qiao, Shichong[4,5,6,7];Qin, Hui[8];Jandt, Klaus D.[3,9,10]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Interfacial Electrochem & Biomat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]Friedrich Schiller Univ Jena, Otto Schott Inst Mat Res OSIM, Chair Mat Sci, D-07743 Jena, Germany;[4]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Coll Stomatol,Dept Implant Dent, Shanghai 200011, Peoples R China;[5]Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China;[6]Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China;[7]Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China;[8]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China;[9]Friedrich Schiller Univ Jena, Jena Ctr Soft Matter JCSM, D-07743 Jena, Germany;[10]Jena Sch Microbial Commun JSMC, Neugasse 23, D-07743 Jena, Germany

年份：2022

卷号：13

期号：3

外文期刊名：JOURNAL OF FUNCTIONAL BIOMATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000858255300001)】；

基金：This work was funded by the National Natural Science Foundation of China (31870945 and 31771022) and the Natural Science Foundation of Shanghai (21ZR1415700). H.C. would like to thank the Alexander von Humboldt Foundation for awarding a Humboldt Research Fellowship.

语种：英文

外文关键词：implantable antibacterial surfaces; polymicrobial infections; surface modification; biocompatibility; tissue integration; bacterial charging; cell-selective surfaces; antibiotic resistance; antimicrobials; protein adsorption

摘要：The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary "proof of concept" studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the "intended use" of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations.