文献类型：期刊文献

英文题名：Synthesis, crystal structure, and properties of 2H-4,8-dimethylfuro[2',3':5,6]naphtho[1,2-b] pyran-2-one, a novel DNA intercalator

作者：Qian, Xuhong[1]; Tao, Zhi-Fu[1]; Wei, Dongzhi[2]; Sun, Jie[3]

机构：[1]E CHINA UNIV SCI & TECHNOL,INST BIOTECHNOL,SHANGHAI 200237,PEOPLES R CHINA;[2]ACAD SINICA,SHANGHAI INST ORGAN CHEM,SHANGHAI 200032,PEOPLES R CHINA

年份：1996

卷号：127

期号：5

起止页码：569

外文期刊名：MONATSHEFTE FUR CHEMIE

收录：;EI(收录号：20242616337239);WOS:【SCI-EXPANDED(收录号:WOS:A1996UM73800013)，CCR-EXPANDED(收录号:WOS:A1996UM73800013)】；

语种：英文

外文关键词：furonaphthopyrone; DNA intercalator; X-ray crystal structure; synthesis

摘要：The furonaphthopyrone 6, a novel DNA intercalator, was synthesized in two steps (ca. 56% overall yield) starting from naphthopyrone 3. The new naphthopyrone derivatives 4 and 6 were fully characterized and the absorption and fluorescence spectroscopic properties of 6 were determined. The dark interactions of furonaphthopyrone 1 and 6 with DNA have been investigated by a fluorescence quenching technique and their apparent Scatchard binding constants were calculated. The crystal structure of 6 was determined. The planarity of 6 and the geometry of the active double bond between the alpha-pyrone and the furan moieties of 6 suggest that furonaphthopyrones are efficient monofunctional DNA intercalators.