文献类型：期刊文献

英文题名：Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

作者：Shen, Luying[1];Pan, Shan[1];Niu, Dechao[1];He, Jianping[1];Jia, Xiaobo[1];Hao, Jina[1];Gu, Jinlou[1];Zhao, Wenru[1];Li, Pei[2];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

年份：2019

卷号：7

期号：5

起止页码：1825

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20191806858241);WOS:【SCI-EXPANDED(收录号:WOS:000466769000037)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2018YFC1105702 and 2016YFA0203700); the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002); the NSFC (Grant No. 51572083, 51572084, 51461165202 and 51472085); the Program of Shanghai Academic/Technology Research Leader (18XD1401400); the Basic Research Program of Shanghai (17JC1404702); the Shanghai Rising-Star Program (16QA1401300); the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; the 111 project (B14018); and the Fundamental Research Funds for Central Universities (222201718002).

语种：英文

外文关键词：Mesoporous materials - Targeted drug delivery - Cytotoxicity - Silica nanoparticles - Sulfur compounds - Biocompatibility - Chemotherapy - Coupling agents - Biodegradation - Controlled drug delivery

摘要：As drug-delivery carriers for cancer chemotherapy, gatekeeper-capped mesoporous silica nanoparticles (MSNs) have been widely studied due to their high drug-loading capability, controlled drug release property and good biocompatibility. However, the currently reported gatekeeper-capped MSNs suffer from complex synthetic procedures, potential toxicity of gatekeepers, unsatisfactory control on drug stimuli-release, etc. In this work, we develop a simple but efficient approach to fabricate PEGylated organosilica-capped mesoporous silica nanoparticles (POMSNs) by employing a disulfide-doped organosilica coating as the gatekeeper formed by the hydrolysis and condensation of a silane coupling agent 3-(mercaptopropyl) trimethoxysilane (MPTMS) to block the mesopores of MSNs. Owing to the glutathione (GSH)-responsive biodegradation behavior of the disulfide-doped organosilica gatekeeper, the DOX-loaded POMSNs exhibit only 20% cell viability towards SMMC-7721 tumor cells, and almost no toxicity towards L-02 cells at a DOX concentration of 50 mu g mL(-1) was measured, demonstrating their selective cytotoxicity in vitro. More importantly, it is demonstrated that the DOX-loaded POMSNs exhibit a tumor inhibition rate of 71.3% and negligible systematic toxicity. Consequently, the resultant POMSNs show great potential as drug nanocarriers for redox-responsive drug release and passive-targeting tumor chemotherapy.