文献类型：期刊文献

英文题名：Magnesium-phosphorus gel containing oxygen vacancy niobium oxide with photothermal property for treating tumor, preventing infection and facilitating bone generation

作者：Zhao, Qinghui[1];Xu, Xiao[1];Zheng, Tianhui[1];He, Bin[1];Zhang, Naixin[1];Wang, Deqiang[2];Wei, Jie[2]

机构：[1]Tongji Univ, Shanghai East Hosp, Shanghai Inst Stem Cell Res & Clin Translat, Natl Stem Cell Translat Resource Ctr,Dept Biobank,, Shanghai 200120, Peoples R China;[2]East China Univ Sci & Technol, Sclool Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：172

外文期刊名：BIOMATERIALS ADVANCES

收录：;EI(收录号：20250917947748);WOS:【SCI-EXPANDED(收录号:WOS:001436655900001)】；

基金：This study was supported by Funding from the Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai, Shanghai Municipal Standardization Pilot Project (S23-04-007) and Shanghai Clinical Research Center for Cell Therapy, China (No. 23J41900100).

语种：英文

外文关键词：Oxygen vacancy niobium oxide; Photothermal therapy; Anti-tumor; Anti-infection; Bone repair

摘要：It is essential to design multifunctional biomaterials for pro-osteogenesis, rooting out residual tumor cells and resisting infection after surgical resection of bone tumors. Herein, niobium oxide with oxygen vacancy (NbOv) was synthesized through a deoxidation reaction, which exhibited photothermal property because of strong light absorption in near-infrared (NIR) region. Subsequently, magnesium-phosphorus gel composite (MP) containing NbOv (MPNOv) was fabricated, which also possessed photothermal property that effectively ablated tumor cells and eradicated bacteria under NIR irradiation in vitro. The in vitro experiments confirmed that compared with MP, MPNOv significantly boosted bone mesenchymal stem cells responses (e.g., propagation and osteoblastic differentiation) due to the presence of NbOv with bioactivity. The in vivo experiments demonstrate that MPNOv fostered bone generation and prevented tumor recurrence as well as infection. In short, MPNOv with good biocompatibility and photothermal property as well as pro-osteogenesis served as a multiple functional biomaterial conquered the tri-challenges: bone defect, tumor recurrence, and bacterial infection in bone tumor therapy. Accordingly, as a novel photothermal therapeutic platform, MPNOv with tumor cells/bacteriaeradicating and pro-osteogenesis ability would be applicable for treatment of bone tumors.