文献类型：期刊文献

英文题名：The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides

作者：Yang, Wu-Lin[1];Liu, Yang-Zi[1];Luo, Shuai[1];Yu, Xingxin[1];Fossey, John S.[2];Deng, Wei-Ping[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

年份：2015

卷号：51

期号：44

起止页码：9212

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000354791400034)，CCR-EXPANDED(收录号:WOS:000354791400034)】；

基金：This work was supported by the Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (No. 21172068 and No. 21402049), the Shanghai Pujiang Program (No. 14PJD013), and Shanghai Yangfan Program (No. 14YF1404600). JSF thanks ECUST for a guest professorship. The Catalysis and Sensing for our Environment (CASE) consortium is thanked for networking opportunities.

语种：英文

摘要：A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to alpha-alkylidene succinimides catalyzed by a novel chiral N,O-ligand/Cu(OAc)(2) system is reported, affording dispiropyrrolidine derivatives with spiro quaternary stereogenic centers in good to excellent yields (up to 90%), excellent levels of diastereoselectivities (>20:1 dr) and enantioselectivities (up to 97% ee).