文献类型：期刊文献

英文题名：Ultra sensitive surface-enhanced Raman scattering detection based on monolithic column as a new type substrate

作者：Li, Qingqing;Du, Yiping[1,2];Tang, Huirong;Wang, Xuan;Chen, Guiping;Iqbal, Jibran;Wang, Wenming;Zhang, Weibing

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

年份：2012

卷号：43

期号：10

起止页码：1392

外文期刊名：JOURNAL OF RAMAN SPECTROSCOPY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000310248400008)】；

基金：This work was supported by the National Natural Science Foundation of China (20975039) and General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China (2011IK226).

语种：英文

外文关键词：monolithic column; surface-enhanced Raman scattering; ultrasensitive detection; Rhodamine 6G (R6G); p-aminothiophenol (PATP)

摘要：A novel ultrasensitive detection method utilizing surface-enhanced Raman scattering (SERS) based on monolithic column was developed in the present study. Monolithic column is a kind of chromatographic stationary phase that contains highly interconnected pores and absorbs chemical components efficiently. Dropping a mixture solution containing analyte, silver colloid, and NaCl on the surface in advance, SERS signals were collected on the surface of the monolithic column. With this method, five commonly used probe molecules of Rhodamine 6G (R6G), p-aminothiophenol, Rhodamine 123, crystal violet, thymine, and two chemicals that are used in agriculture (paraquat and flusilazole) were detected. Especially, R6G and p-aminothiophenol can be detected at extremely low concentrations of 1018 and 1016 mol/L at milliliter level, respectively. The enhancement factor was calculated to be approximately 1014 for R6G detection. The results suggest that the monolithic column does improve the sensitivity of SERS detection dramatically and the topography of the monolithic column is essential for the enhancement. The easy operability and the significant enhancement are the greatest advantages of this method. Copyright (c) 2012 John Wiley & Sons, Ltd.