文献类型：期刊文献

英文题名：Bio-Conjugated Advanced Materials for Targeted Disease Theranostics

作者：Hu, Xi-Le[1];Kwon, Nahyun[4];Yan, Kai-Cheng[1];Sedgwick, Adam C.[2];Chen, Guo-Rong[1];He, Xiao-Peng[1];James, Tony D.[3];Yoon, Juyoung[4]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Res Lab Precis Chem & Mol Engn,Key Lab Adv Mat &, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Austin, TX 78712 USA;[3]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England;[4]Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

年份：2020

卷号：30

期号：13

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20200608129675);WOS:【SCI-EXPANDED(收录号:WOS:000510469400001)】；

基金：X.-L.H. and N.K. contributed equally to this work. The authors thank the Natural Science Foundation of China (Nos. 21788102, 91853201, 21722801, and 21776078), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202) and the Shanghai Science and Technology Committee (No. 19410712600). J.Y. thanks the National Research Foundation of Korea (NRF), which was funded by the Korea government (MSIP) (No. 2012R1A3A2048814). T.D.J. thanks the Royal Society for a Wolfson Research Merit Award.

语种：英文

外文关键词：advanced materials; aptamers; biomolecules; peptides; theranostics

摘要：Human beings are "machines" that use endogenously produced biomolecules as "components" in signaling and for the maintenance of the body. These biomolecules consist of proteins, nucleic acids, and carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. These biomolecules have the ability to recognize/interact with other biomolecules that are overexpressed in disease cells. For targeted theranostics, strategies to chemically incorporate these natural biomolecules with advanced materials to treat human diseases by imaging-guided drug delivery or photodynamic/photothermal therapy are proposed, with improved biocompatibility. Herein, recent research on construction of quantum dots, nanoparticles, and 2D material platforms decorated with antibodies, peptides, nucleic acid aptamers, carbohydrates, and folic acid for targeted diagnosis and treatment are summarized and discussed. In addition, the various strategies required to construct effective functional materials for targeted cancer therapy are highlighted. The hope is that this review can inspire and guide those that are interested in the field of biomedicine to rationally design and develop new target-based theranostic materials.