文献类型：期刊文献

英文题名：Mild and Copper-Free Stereoselective Cyanation of gem-Difluoroalkenes by Using Benzyl Nitrile as a Cyanating Reagent

作者：Zhang, Juan[1];Xu, Chengyuan[1];Wu, Wei[1];Cao, Song[1]

机构：[1]ECUST, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2016

卷号：22

期号：29

起止页码：9902

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20162902601237);WOS:【SCI-EXPANDED(收录号:WOS:000380271900003)，CCR-EXPANDED(收录号:WOS:000380271900003)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21472043 and 21272070).

语种：英文

外文关键词：alkenes; benzyl nitrile; cyanation; fluorinated alkenyl nitrile; fluorine

摘要：A novel copper-free highly stereoselective cyanation of gem-difluoroalkenes by using benzyl nitrile as a cyanating reagent with the assistance of tBuOLi under air atmosphere at room temperature was developed. A variety of versatile fluorinated alkenyl nitriles were obtained. The proposed mechanism involved the C-H bond oxidation, C-CN bond cleavage, and then nucleophilic vinylic substitution (SNV).