文献类型：期刊文献

英文题名：Poly(lactic acid)-coated mesoporous silica nanosphere for controlled release of venlafaxine

作者：Tang, Jing[1,2,3];Slowing, Igor I.[1];Huang, Yulin[1];Trewyn, Brian G.[1];Hu, Jun[2,3];Liu, Honglai[2,3];Lin, Victor S. -Y.[1]

机构：[1]Iowa State Univ, Dept Chem, Ames, IA 50011 USA;[2]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2011

卷号：360

期号：2

起止页码：488

外文期刊名：JOURNAL OF COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20112514074844);WOS:【SCI-EXPANDED(收录号:WOS:000292066100022)】；

基金：This work is supported by the National Natural Science Foundation of China (Nos. 20776045, 20736002), Program for Changjiang Scholars and Innovative Research Team in University of China (No. IRT0721) and the 111 Project (Grant B08021) of China.

语种：英文

外文关键词：Venlafaxine; Mesoporous materials; Controlled release

摘要：Two types of mesoporous silica nanospheres (MSNs) were synthesized for use as controlled-release agents. One was prepared by grafting with 5,6-dihydroxyhexylsilane (DH-MSN) and the other one by further coating with cholic acid-crosslinked poly(lactic acid) (CA-PLA-MSN). We studied the release of the antidepressant venlafaxine from each of the materials in simulated gastric fluid (SGF), in simulated gastric acid solution (SGA), and in simulated intestinal fluid without pancreatin (SIF). The CA-PLA-MSN material was able to significantly delay the release of the drug in intestinal condition compared with gastric acid surrounding due to the fast decomposition rate of PLA in gastric acid. Moreover, it successfully avoided the initial burst to a certain extent in SGF. The enzyme pepsin played a favorable obstruct role in both DH-MSN and CA-PLA-MSN systems to reduce release rate. A model based on Weibull model was built to fit the release results, and based on it, the mechanisms about release processes were brought out tentatively. (C) 2011 Elsevier Inc. All rights reserved.