文献类型：期刊文献

中文题名：mPEG-PLA嵌段共聚物及其胶束的降解行为研究

英文题名：Degradation behavior of mPEG-PLA block copolymer and its micelles

作者：吴菁菁[1];张文明[2];周秦鹏[1];张新晴[1];陆冲[1]

机构：[1]华东理工大学材料科学与工程学院生态材料研究室,上海200237;[2]上海谊众药业股份有限公司,上海201401

年份：2022

卷号：36

期号：11

起止页码：7

中文期刊名：中国塑料

外文期刊名：China Plastics

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

语种：中文

中文关键词：聚丙交酯;共聚物;载药胶束;降解

外文关键词：poly lactide;copolymer;drug-loaded micelle;degradation

摘要：采用开环聚合法制备了聚乙二醇单甲醚(mPEG)与D,L-丙交酯的嵌段共聚物,并以此共聚物为载体制备了紫杉醇胶束,研究了mPEG-聚丙交酯(PLA)与载药胶束(DMs)在不同条件下的降解特点。结果表明,在低温下(4℃),mPEG-PLA聚合物和DMs均能长时间(24个月)保持稳定,未发生明显降解;当温度升高,mPEG-PLA和DMs降解速度明显增加,但降解机理有所不同,这种差异在40℃以上的环境中更明显;mPEG-PLA聚合物的高温(60℃)降解以链段内部无规则断裂为主,分子量显著降低;DMs在高温(60℃)下则更多遵循“末端降解机理”,生成更多的丙交酯和乳酸。
Poly(ethylene glycol monomethyl ether-co-poly lactide)(mPEG-PLA)was prepared through ring opening polymerization of methoxy poly(ethylene glycol)and D,L-lactide,and then the mPEG-PLA/paclitaxel drug-loaded micelles(DMs)was prepared. The degradation characteristics of mPEG-PLA and drug-loaded micelles were studied under different conditions. The results indicated that mPEG-PLA and DMs kept stable at a low temperature of 4 ℃ even for a long period of 24 months. The degradation rates of mPEG-PLA and DMs improved with an increase in temperature,but their degradation mechanisms were different,especially at temperature above 40 ℃. The degradation of mPEG-PLA was dominated by the random fracture inside the segment,resulting in a significant decrease in molecular weight. However,there was no obvious increase in the contents of lactide and lactic acid. The degradation mechanism of DMs was more possibly attributed to the“chain-end scission rule”at a high temperature of 60 ℃. This means the depolymerization at the terminal,leading to the production of more amounts of lactide and lactic acid.