文献类型：期刊文献

英文题名：Electrostatically Stabilized Light-Activated Membrane Delivery System: Overcoming Membrane Flexibility and Self-Repair to Enhance Tumor Therapy

作者：Zhang, Cuiyun[1];Shi, Yiqi[1];Zhu, Zhirong[1,2];Yang, Ting[1];Wang, Yuwei[1];Hu, Shanshan[1];Wu, Qi[1];Yang, Haojian[1];Liu, Jihong[1];Zhu, Wei-Hong[1,3];Wang, Qi[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Inst Fine Chem,Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn,Key Lab Adv Mat & Joint Int Re, Shanghai, Peoples R China;[2]Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Peoples R China;[3]East China Univ Sci & Technol, Ctr Photosensit Chem Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：19

期号：12

起止页码：12119

外文期刊名：ACS NANO

收录：;EI(收录号：20251218083508);WOS:【SCI-EXPANDED(收录号:WOS:001456833500001)】；

基金：This work was supported by the National Key Research and Development Program of China (2021YFA0910000, 2024YFA1803501), NSFC Excellent Young Scientist (EYS) Scheme (22222803), NSFC Science Center Program (21788102), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), NSFC/China (22408105, 22404056), Fellowship of China National Postdoctoral Program for Innovative Talents (BX20240114), China Postdoctoral Science Foundation (2022M72142).

语种：英文

外文关键词：cell membrane-coated delivery systems; electrostaticstabilization; light-activated membrane disruption; reactive oxygen species; photodynamic therapy; aggregation induced emission

摘要：Cell membrane-coated nanoparticle-based delivery systems often struggle with inevitable drug leakage during the delivery process and inefficient drug release at the tumor site, resulting in unsatisfactory antitumor outcomes. Here, we present an electrostatically stabilized light-activated membrane delivery system (Hybrid membrane nanoparticles, [Hm]@NPs) for leak-free drug delivery, coupled with precisely site-specific and controllable drug release, to elevate cancer treatment. [Hm]@NPs are constructed by encapsulating an aggregation-induced emission (AIE) photosensitizer (Phenalen-1-one-quinoline malonitrile-thiophene tribenamine, Phe-Qui-T) into a positively charged reactive oxygen species (ROS)-responsive polymer (F127-TP-U11) to form a positively charged nanoparticle and then coating it with a negatively charged hybrid membrane containing red blood cell membrane and Panc-1 cell membrane. [Hm]@NPs with high stability effectively prevent drug leakage through electrostatic interaction between the hybrid membrane and nanoparticle. Simultaneously, the photosensitizer Phe-Qui-T with light-controlled ROS generation efficiently destroys both the ROS-responsive polymer and the hybrid membrane, ensuring precise and sufficient drug release while enabling photodynamic therapy (PDT), thereby augmenting antitumor efficacy. [Hm]@NPs show impressive tumor inhibition in pancreatic cancer mouse models, highlighting the potential of this light-controlled membrane-disruption strategy for advanced cell membrane-coated nanodelivery system design.