文献类型：期刊文献

英文题名：Injectable Biomimetic Hydrogel Guided Functional Bone Regeneration by Adapting Material Degradation to Tissue Healing

作者：Li, Yamin[1];Xiao, Lan[2];Wei, Daixu[3];Liu, Shengyang[4];Zhang, Zeren[4];Lian, Ruixian[4];Wang, Liren[1];Chen, Yunsu[1];Jiang, Jia[1];Xiao, Yin[2,5];Liu, Changsheng[4];Li, Yulin[4];Zhao, Jinzhong[1]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Shanghai 200233, Peoples R China;[2]Queensland Univ Technol, Sch Mech Med & Proc Engn, Ctr Biomed Technol, 60 Musk Ave, Brisbane, Qld 4059, Australia;[3]Northwest Univ, Dept Life Sci & Med, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Peoples R China;[4]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Engn Res Ctr Biomed Mat,Minist Educ,Key Lab Ultraf, Shanghai 200237, Peoples R China;[5]Griffith Univ, Sch Med & Dent, Gold Coast, Qld 4222, Australia

年份：2023

卷号：33

期号：19

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20231013693142);WOS:【SCI-EXPANDED(收录号:WOS:000943192400001)】；

基金：Y.L., L.X., and D.W. contributed equally to this work. This study was supported by the National Key Research and Development Program of China (grant nos. 2018YFC1106200 and 2018YFC1106202), the National Natural Science Foundation of China (grant nos. 81871753 and 31900950), Shanghai Sailing Program (21YF1433900), The 72nd Postdoctoral Science Foundation of China (2022M720090) and Research project of Shanghai Municipal Health and Family Planning Commission (201840032). All animal protocols used in this study have been approved by the Institutional Animal Care and Use Committee (IACUC) of Shanghai Jiao Tong University school of Medicine affiliated with sixth people's hospital and performed in accordance with the guidelines of the IACUC (approval nr.: DWSY2017-100).

语种：英文

外文关键词：biomimetic microstructures; degradation suitability; functional bone regeneration; injectable hydrogels; osteogenesis

摘要：The treatment of irregular bone defects remains a clinical challenge since the current biomaterials (e.g., calcium phosphate bone cement (CPC)) mainly act as inert substitutes, which are incapable of transforming into a regenerated host bone (termed functional bone regeneration). Ideally, the implant degradation rate should adapt to that of bone regeneration, therefore providing sufficient physicochemical support and giving space for bone growth. This study aims to develop an injectable biomaterial with bone regeneration-adapted degradability, to reconstruct a biomimetic bone-like structure that can timely transform into new bone, facilitating functional bone regeneration. To achieve this goal, a hybrid (LP-CPC@gelatin, LC) hydrogel is synthesized via one-step incorporation of laponite (LP) and CPC into gelatin hydrogel, and the LC gel degradation rate is controlled by adjusting the LP/CPC ratio to match the bone regeneration rate. Such an LC hydrogel shows good osteoinduction, osteoconduction, and angiogenesis effects, with complete implant-to-new bone transformation capacity. This 2D nanoclay-based bionic hydrogel can induce ectopic bone regeneration and promote ligament graft osseointegration in vivo by inducing functional bone regeneration. Therefore, this study provides an advanced strategy for functional bone regeneration and an injectable biomimetic biomaterial for functional skeletal muscle repair in a minimally invasive therapy.