文献类型：期刊文献

英文题名：Hierarchically macroporous/mesoporous POC composite scaffolds with IBU-loaded hollow SiO2 microspheres for repairing infected bone defects

作者：Chen, Fangping[1,2,3];Song, Zhiyan[1,3];Gao, Li[1,2];Hong, Hua[1,2];Liu, Changsheng[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Shanghai 200237, Peoples R China

年份：2016

卷号：4

期号：23

起止页码：4198

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20162502513761);WOS:【SCI-EXPANDED(收录号:WOS:000378268700016)】；

基金：This investigation was supported by the National Basic Research Program of China (973 Program: 2012CB933600), National Natural Science Foundation of China (No. 31370960, No. 31100678) and the 111 Project (B14018).

语种：英文

外文关键词：Controlled drug delivery - Defects - Escherichia coli - Calcium compounds - Repair - Scaffolds - Biocompatibility - Bone - Targeted drug delivery - Cell culture - Microspheres - Scaffolds (biology)

摘要：Infected bone defects are normally regarded as contraindications for bone repair. In the present study, a hollow mesoporous structure of silica (SiO2) microspheres was first synthesized and loaded with ibuprofen (IBU). Poly(1,8-octanediol-co-citrate) (POC) and beta-tricalcium phosphate (beta-Ca-3(PO4)(2), beta-TCP), together with IBU-loaded SiO2 were fabricated by a 3D printing technique based on the Freeform Fabrication System with Micro-Droplet Jetting (FFS-MDJ). The physiochemical properties, compressive modulus, drug release behavior, antimicrobial properties and cell response of the composite scaffold were systematically investigated. The developed IBU-loaded SiO2/beta-TCP/POC scaffolds presented a highly interconnected porous network, macropores (350-450 mu m) and mesopores (3.65 nm), as well as proper compressive modulus and biocompatibility. The addition of hollow SiO2 microspheres was found to decrease the burst release and increase the cumulative release amount of IBU. In addition, IBUloaded SiO2/beta-TCP/POC showed a long-term effect on inhibiting E. coli growth by agar diffusion. The result indicated that the IBU-loaded SiO2/beta-TCP/POC scaffold, with a hierarchically macro/mesoporous, highly interconnected pore structure and an effective antimicrobial property, demonstrates promise for bone regeneration in the clinical case of infected bone defects.