文献类型：期刊文献

英文题名：Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement

作者：Zhang, Jian[1];Su, Jia-Yi[2];Liu, Yang-Zi[1];Li, Hao[2];Wang, Quannan[1];Deng, Wei-Ping[1,2]

机构：[1]Zhejiang Normal Univ, Coll Chem & Mat Sci, Jinhua 321004, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2023

卷号：66

期号：10

起止页码：2810

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20233814736642);WOS:【SCI-EXPANDED(收录号:WOS:001066153800001)】；

基金：This work was supported by the National Key Research and Development Program of China (2021YFA0804900), the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (2022R01007), and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism.

语种：英文

外文关键词：palladium; umpolung; allylic alkylation; Pudovik addition; [1,2]-phospha-Brook rearrangement

摘要：Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed. The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way. This cascade reaction proceeds under mild conditions with excellent functional group compatibility. Furthermore, the catalytic asymmetric version has also been explored.