文献类型：期刊文献

中文题名：一种N-杂环卡宾催化合成氘代苯偶姻的方法

英文题名：A Method for the Synthesis of Deuterated Benzoins Catalyzed by N-Heterocyclic Carbene

作者：张心予[1];耿慧慧[1];张士磊[1];王卫[1];陈晓蓓[1]

机构：[1]华东理工大学药学院、上海市细胞代谢光遗传学技术前沿科学研究基地、上海市新药设计重点实验室生物反应器工程国家重点实验室,上海200237

年份：2023

卷号：43

期号：4

起止页码：1510

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000974926300019)】；北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：Project supported by the National Natural Science Foundation of China (Nos. 22071053, 22271206), the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

语种：中文

中文关键词：氘代;重水;苯偶姻缩合;N-杂环卡宾;有机催化

外文关键词：deuteration;deuteroxide;benzoin condensation;N-heterocyclic carbene;organocatalysis

摘要：利用D2O作为氘源,在N-杂环卡宾的催化下,两分子醛发生苯偶姻缩合反应(benzoin condensation)得到酮基α-位氘代的苯偶姻产物.反应条件温和、操作简单,多种芳香醛底物都可以给出高氘代率的产物.
An efficient method has been developed for the synthesis of deuterated benzoins from two molecules of aldehydes under the catalysis of N-heterocyclic carbene by using D2O as the deuterium source,providing the products with deuterium selectively incorporated at theα-position of ketone group.The method features simple operation and mild reaction conditions,and a variety of aromatic aldehyde substrates could afford products with high deuterium incorporation.