文献类型：期刊文献

英文题名：Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release

作者：Shi, Ben[1,2];Ren, Ning[3,4];Gu, Luyan[1,2];Xu, Ge[1,2];Wang, Rongchen[1,2];Zhu, Tianli[1,2];Zhu, Ying[3,4];Fan, Chunhai[5,6];Zhao, Chunchang[1,2];Tian, He[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys,Shanghai Synchrotron Radi, Shanghai Adv Res Inst,Div Phys Biol,Zhangjiang La, Shanghai 201800, Peoples R China;[4]Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys,Bioimaging Ctr, Shanghai Adv Res Inst,Zhangjiang Lab,Shanghai Syn, Shanghai 201800, Peoples R China;[5]Shanghai Jiao Tong Univ, Renji Hosp, Sch Chem & Chem Engn, Sch Med, Shanghai 200240, Peoples R China;[6]Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Sch Med, Shanghai 200240, Peoples R China

年份：2019

卷号：58

期号：47

起止页码：16826

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20194407606319);WOS:【SCI-EXPANDED(收录号:WOS:000489786000001)】；

基金：We gratefully acknowledge the financial support by the National Natural Science Foundation of China (21874043, 21788102, 21672062, 11675251, 21834007), Shanghai Municipal Science and Technology Major Project (Grant No.2018SHZDZX03), the National Key R&D Program of China (2016YFA0400900), the Key Research Program of Frontier Sciences and CAS (Grant NO. QYZDJSSW-SLH031).

语种：英文

外文关键词：cancer; drug delivery; fluorescence; nanostructures; theranostics

摘要：NIR light responsive nanoplatforms hold great promise for on-demand drug release in precision cancer medicine. However, currently available systems utilize "always-on" photothermal transducers that lack target specificity, and thus inaccurately differentiate tumors from normal tissues. Developed here is a theranostic nanoplatform featuring H2S-mediated in situ production of NIR photothermal agents for imaging-guided and photocontrolled drug release. The system targets H2S-rich cancers. This nanoplatform shows H2S-activatable NIR-II emission and NIR light controllable release of the drug Camptothecin-11. Upon administering the system to HCT116 tumor-bearing mice, the tumor is greatly suppressed with minimal side effects, arising from the synergy of the cancer-specific and NIR light activated therapy. This theranostic nanoplatform thus sheds light on precision medicine with guidance through NIR-II imaging.