文献类型：期刊文献

中文题名：Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

作者：Lan Jiang[1,2];Tianji Zhang[3];Hongzhong Lu[4];Saijuan Li[5];Kangjie Lv[2];Alex Tuffour[2];Lixin Zhang[2];Kan Ding[5];Jin-Ping Li[6,7];Hongmei Li[3];Xueting Liu[2]

机构：[1]Department of Cardiothoracic Surgery,Children’s Hospital of Nanjing Medical University,Nanjing,210093,China;[2]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237,China;[3]Division of Chemistry and Analytical Science,Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation,National Institute of Metrology,Beijing,100029,China;[4]State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai,200240,China;[5]Glycochemistry&Glycobiology Lab,Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China;[6]International Research Center for Soft Matter,Beijing University of Chemical Technology,Beijing,100029,China;[7]Department of Medical Biochemistry and Microbiology,University of Uppsala,Uppsala,Sweden

年份：2023

卷号：8

期号：1

起止页码：11

中文期刊名：Synthetic and Systems Biotechnology

外文期刊名：合成和系统生物技术（英文）

收录：Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：support from the National Key Research and Development Program of China (2021YFF0600700,2020YFA090032 and 2019YFA0906201);the Swedish research council (2020-05759);the National Natural Science Foundation of China (31720103901,31961133004,21907031,21977029,22108266).

语种：英文

中文关键词：Heparin;Biosynthesis;Biological activities;Bio-production

摘要：The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy.Moreover,after more than 2 years,many populations are still under pressure of infection.Thus,a broader perspective in developing antiviral strategies is still of great importance.Inspired by the observed multiple benefits of heparin in the treatment of thrombosis,the potential of low molecular weight heparin(LMWH)for the treatment of COVID-19 have been explored.Clinical applications found that LMWH decreased the level of inflammatory cytokines in COVID-19 patients,accordingly reducing lethality.Furthermore,several in vitro studies have demonstrated the important roles of heparan sulfate in SARS-CoV-2 infection and the inhibitory effects of heparin and heparin mimetics in viral infection.These clinical observations and designed studies argue for the potential to develop heparin mimetics as anti-SARS-CoV-2 drug candidates.In this review,we summarize the properties of heparin as an anticoagulant and the pharmaceutical possibilities for the treatment of virus infection,focusing on the perspectives of developing heparin mimetics via chemical synthesis,chemoenzymatic synthesis,and bioengineered production by microbial cell factories.The ultimate goal is to pave the eminent need for exploring novel compounds to treat coronavirus infection-caused diseases.