文献类型：期刊文献

英文题名：Hollow silica-polyelectrolyte composite nanoparticles for controlled drug delivery

作者：Yang, Qingsong[1];Li, Li[1];Zhao, Fang[1];Han, Haoya[1];Wang, Weihua[2];Tian, Yuchuan[1];Wang, Yunwei[1];Ye, Zhishuang[1];Guo, Xuhong[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Alle Chem Co, Qingdao 266000, Peoples R China;[3]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2019

卷号：54

期号：3

起止页码：2552

外文期刊名：JOURNAL OF MATERIALS SCIENCE

收录：;EI(收录号：20184305984859);WOS:【SCI-EXPANDED(收录号:WOS:000450016100054)】；

基金：We gratefully thank the financial support by the NSFC Grants (5171101370, 51773061 and 21476143) and 111 Project Grant (B08021). We also thank Shanghai Synchrotron Radiation Facility for its experimental support.

语种：英文

外文关键词：Covalent bonds - X ray scattering - Sulfur compounds - Targeted drug delivery - Polyelectrolytes - Composite materials - Dynamic light scattering - Silica nanoparticles

摘要：The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica--polyelectrolyte composite nanoparticle, was successfully prepared by using a template of spherical polyelectrolyte brush (SPB) which consists of a polystyrene (PS) core and a densely grafted linear poly(acrylic acid) (PAA) shell. The existence of PAA chains and introduction of disulfide bonds in silica framework endow the composite nanoparticles with pH and GSH dually responsive properties which were confirmed by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). With doxorubicin hydrochloride (DOX) as the model drug, the loading content and encapsulation efficiency could reach up to 43% and 96%, respectively. The drug release behavior was investigated under various environments, showing that the drug release rate increased with the decrease in pH value and the increase in GSH concentration. The prepared hollow SiO2-PAA composite nanoparticles possess a great potential as carriers for controlled drug delivery.