文献类型：期刊文献

英文题名：Single-visible-light-modulated photoswitches with aggregation-induced emission for super-resolution imaging

作者：Fang, Xiaowei[1,2,3];Jin, Pengwei[1,2,3];Li, Fanghui[1,2,3];Zhang, Tongyun[1,2,3];Zhang, Zehan[1,2,3];Li, Mengqi[1,2,3,4];Zhu, Wei-Hong[1,2,3,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Green Chem Engn & Ind Catalysis, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem,Frontiers Sci Ctr Materiobiol & Dyn, Ctr Photosensit Chem Engn,Feringa Nobel Prize Scie, Shanghai 200237, Peoples R China;[4]Guangxi Lab Low Carbon Technol & Green Chem Adv Ma, Qinzhou 535008, Guangxi, Peoples R China

年份：2026

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20263321288807);Scopus(收录号：2-s2.0-105046990902);WOS:【SCI-EXPANDED(收录号:WOS:001845815300001)】；

基金：This work was supported by Basic Science Center of National Natural Science Foundation (NSFC, T2488302), National Natural Science Foundation (NSFC, 92356301, 22338006, 22578123, 22305079), Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM404), Natural Science Foundation of Shanghai (25ZR1402102), Shanghai Sailing Program (23YF1409000), Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (24CGA29), Guangxi Science and Technology Innovation Platform Program ("Leitai" Action Plan-Guangxi Laboratory Capacity Building, LT2504240035). The authors thank the staff members of the Integrated Laser Microscopy System at the National Facility for Protein Science in Shanghai (NFPS), Shanghai Advanced Research Institute, Chinese Academy of Sciences, China, for data collection and analysis.

语种：英文

外文关键词：Diffraction - Fluorescence imaging - Light modulation - Optical resolving power

摘要：Super-resolution fluorescence imaging (SRI) overcomes the traditional optical diffraction limit, enabling the visualization of microstructures at the nanoscale. Central to this technique is the precise photo-modulation of molecular fluorescence emission, yet it remains a formidable challenge to develop visible-light-responsive photoswitching systems with aggregation-induced emission (AIE) that are biocompatible and suitable for solid-state applications. Herein, we construct a series of unique fluorescent photoswitches with single-visible-light modulation by incorporating sulfone units into a sterically hindered diarylethene. By introducing sulfone units and adjusting the substituent effect, the fluorescent photoswitches exhibit band-tail absorption, demonstrating superior single-visible-light-stimulation ability (488 or 561 nm light) and efficiently preventing damage from short-wavelength light. Notably, the weak pi-pi stacking and the activated restriction of intramolecular vibration (RIV) process, caused by the large, bulky ethylene bridge, also endow the fluorescent photoswitch with unique aggregation-induced emission properties. Thus, such fluorescent photoswitches exhibit fluorescence emission with a high fluorescent quantum yield and on-off ratio (>100) in the aggregated state, which successfully enables a single long-wavelength 561 nm laser, a privileged source, to perform Stochastic Optical Reconstruction Microscopy (STORM) imaging of nano-micelles with high resolution. This work offers a robust photonics-based approach to the development of remote and non-invasive fluorescence modulation platforms, fundamentally advancing the frontiers of SRI techniques.