文献类型：期刊文献

英文题名：Photodynamic and Its Concomitant Ion-Interference Synergistic Therapies Based on Functional Hierarchically Mesoporous MOFs

作者：He, Miao[1];Li, Ke[1];Yang, Jian[1];Wang, Qinghua[1];Gu, Jinlou[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2022

卷号：18

期号：39

外文期刊名：SMALL

收录：;EI(收录号：20223612678263);WOS:【SCI-EXPANDED(收录号:WOS:000846632600001)】；

基金：This work was financially supported by the Natural Science Foundation of China (21975072, 51902106, and 52103314), Chenguang Plan of Shanghai Education Development Foundation (21CGA38) and the Natural Science Foundation of Shanghai (18ZR1408700). All animal experiments were performed in compliance with the Guidelines for the Care and Use of Research Animals established by the East China University of Science and Technology Animal Studies (ECUST-2020-04001).

语种：英文

外文关键词：black phosphorus quantum dots; controllable ion-interference therapy; hierarchical mesopores; metal-organic frameworks; synergistic therapy

摘要：Although ion-interference therapy (IIT) has become an intriguing option for cancer treatment, the generation of interference ions on-demand remains a challenge. Herein, a nanoplatform based on hierarchically mesoporous metal-organic frameworks (HMMOFs) is adopted to integrate black phosphorus quantum dots (BPQDs) and meso-tetra(4-carboxyphenyl) porphine (TCPP) to realize controllable phosphate anions (PAs) production in a specific cancerous region for IIT. The uniform large mesopores of HMMOFs could guarantee the selective screening and immobilization of ultra-small and monodispersed BPQDs. The TCPP in microporous domains of HMMOFs could effectively produce O-1(2), which not only serves as photosensitizer for photodynamic therapy (PDT), but also switches on the release of PAs from BPQDs in the adjacent mesoporous domains to trigger the concomitant synergetic IIT. The elaborated nanoplatform (BP@HMUiO-66-TCPP) presents good biocompatibility, biodegradability as well as enhanced synergetic therapeutic effects. In murine models treated with BP@HMUiO-66-TCPP, the tumor inhibition rate is as high as approximate to 98.24% as compared to that of the control group after 14 days treatment. Moreover, the tumor volumes in the synergetic group are only 19.6% of those in the PDT alone treated group. Such a concept of exogenous photo-controlled synergistic therapeutics might be extended to a broad range of IIT for an improved antitumor efficacy.