文献类型：期刊文献

英文题名：A revisit to the Hantzsch reaction: Unexpected products beyond 1,4-dihydropyridines

作者：Shen, Li[1];Cao, Song[1];Wu, Jingjing[1];Zhang, Jian[1];Li, Hui[1];Liu, Nianjin[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Ctr Fluorine Chem Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2009

卷号：11

期号：9

起止页码：1414

外文期刊名：GREEN CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000269493700020)】；

基金：Financial support from the National High Technology Research and Development Program of China (863 Program, 2006AA10A201), the Shanghai Foundation of Science of Technology (073919107), the Shanghai Leading Academic Discipline Project (B507), the National Key Project for Basic Research (973 Project, 2007BAQ03771), and the Shanghai Education Commission are kindly acknowledged.

语种：英文

摘要：A novel green and efficient one-pot three-component synthesis of 2-aryl-pyridines in good to excellent yields has been reported. The methodology initially involved the formation of 1,2-dihydropyridine intermediates via reaction of a variety of aromatic aldehydes with ethyl (methyl) acetoacetate and ammonium acetate, which were the same starting materials as the Hantzsch reaction, under solvent-, catalyst-and heat-free (at room temperature) conditions, followed by air oxidation for 72 hours. In this paper, we also systematically reinvestigated the classic Hantzsch reaction under different reaction conditions, analyzed the main products as well as byproducts, corrected some mistakes in the literature and elucidated the reaction mechanism.