文献类型：期刊文献

英文题名：Amino-functionalized ionic liquid as a nucleophilic scavenger in solution phase combinatorial synthesis

作者：Song, GH; Cai, YQ; Peng, YQ

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Inst Pesticides & Pharmaceut, Shanghai 200237, Peoples R China

年份：2005

卷号：7

期号：4

起止页码：561

外文期刊名：JOURNAL OF COMBINATORIAL CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000230529200013)，CCR-EXPANDED(收录号:WOS:000230529200013)】；

语种：英文

摘要：A new functionalized ionic liquid, 1-aminoethyl-3-methylimidazolium hexafluorophosphate was synthesized from 1-methylimidazole and 2-bromoethylamine hydrobromide. This ionic liquid was found to be an efficient scavenger for removing excess electrophiles, such as benzoyl chloride, p-toluenesulfochloride, phenyl isothiocyanate, and p-chlorophenyl isocyanate, in a solution-phase parallel synthesis. The resulting ionic liquid derivatives can be separated directly from the reaction mixture. Desired products were obtained with high purity. Only 1.5-2.0 equiv of this scavenger was needed with a sequestration time of less than 35 min. In addition, the used ionic liquid can be regenerated and recycled several times without significant loss of activity.