文献类型：期刊文献

英文题名：Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China

作者：Zuo, Shaoqi[1];Meng, Haoyu[1];Liang, Jiahui[1];Zhen, Huajun[2];Zhu, Ying[1];Zhao, Yanbin[1];Zhang, Kun[1];Dai, Jiayin[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, State Environm Protect Key Lab Environm Hlth Impa, Shanghai 200240, Peoples R China;[2]East China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China

年份：2022

卷号：56

期号：4

起止页码：2312

外文期刊名：ENVIRONMENTAL SCIENCE & TECHNOLOGY

收录：;EI(收录号：20220811688745);WOS:【SCI-EXPANDED(收录号:WOS:000763099700023)】；

基金：This study was supported by the Shanghai Pujiang Program (19PJ1404800 and 19PJ1404900) and the National Natural Science Foundation of China (21976121, 22006099 and 41977359).

语种：英文

外文关键词：cardiovascular drugs; lipid-lowering drugs; contamination in surface water; field investigation; model simulation; developmental toxicity; risk potential

摘要：The residues of pharmaceuticals in surface waters of megacities and ecotoxicological implications are of particular concern. In this study, we combined field investigations and model simulations to explore the contamination of cardiovascular and lipid-lowering drugs, one group of the most prescribed medications globally, in surface waters of a typical megacity, Shanghai, with a high wastewater treatment ratio (approximate to 96%). Among 26 target substances, 19 drugs were detected with aqueous concentrations ranging from 0.2 (ketanserin) to 715 ng/L (telmisartan). Of them, angiotensin II receptor antagonists, telmisartan and irbesartan, were dominant besides beta-blockers. Spatial distribution analysis demonstrated their much higher levels in tributaries compared to the mainstream. The results of model simulations and field investigation revealed relatively low concentrations of cardiovascular and lipid-lowering drugs in surface waters of Shanghai compared to other cities in highly developed countries, which is associated with low per capita usage in China. Ecotoxicological studies in zebrafish embryos further revealed developmental effects, including altered hatching success and heart rate, by irbesartan, telmisartan, lidocaine, and their mixtures at ng/L concentrations, which are typical levels in surface waters. Overall, the present results suggest that the high wastewater treatment ratio was not sufficient to protect fish species in the aquatic ecosystem of Shanghai. Exposure to cardiovascular and lipid-lowering drugs and associated risks will further increase in the future due to healthcare improvements and population aging.