文献类型：期刊文献

英文题名：Quadruple functionalized copper-polydopamine nanoparticles for tumor-specific multimodal enhancing photodynamic therapy with low skin phototoxicity

作者：Zhong, Tianyu[1];Wang, Qinghua[1];Jiang, Cong[2];Hao, Jina[1];Guan, Mengjia[1];Dai, Bin[3];Jiang, Quan[4];Zhang, Yong[4];Cao, Yuanyuan[1];Li, Yongsheng[1,3]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn,Key Lab Ultrafine Mat,Lab Low D, Shanghai 200237, Peoples R China;[2]Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai 200092, Peoples R China;[3]Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Peoples R China;[4]Fudan Univ, Dept Gen Surg, Zhongshan Hosp, Shanghai 200032, Peoples R China

年份：2023

卷号：35

外文期刊名：APPLIED MATERIALS TODAY

收录：;EI(收录号：20234715095079);WOS:【SCI-EXPANDED(收录号:WOS:001118532500001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (grant no. 2022YFC2403200) , National Natural Science Foundation of China (grant nos. 22005096, 51972112) , The Key Field Research Program (grant no. 2023AB054) , Basic Research Program of Shanghai (grant no. 21JC1406003) , Shanghai Sailing Program (grant no. 20YF1410100) and Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Stimulation-activated photodynamic therapy; GSH response; ROS amplification; Polydopamine

摘要：The photoactivity quenching and recovering efficiency are essential for effective stimulation-activated photodynamic therapies (PDT). To maximum the interactions between quencher and photosensitizer in silent state and to scavenge quenchers in active state, a simple GSH-responsive PDT nanomedicine is designed as chlorin e6 (Ce6) loading arginine-copper-polydopamine coordination nanoparticles (Ce6-ACuPDA), which show quadruple functions attributed to the redox-responsive binding and quenching abilities of copper. The photosensitivity of Ce6 is dually quenched directly by the drug-loading substrate and recovers in cancer cells due to the GSHtriggered collapsing of Cu-PDA networks and the reduction of quenchers (Cu(II)). Meanwhile, the Cu(II) oxidates GSH to weaken the cancerous redox barrier and elevates the ultimate efficacy of PDT, which endows the nanomedicine with superior anti-cancer efficacies and low skin phototoxicities. This designing principle focusing on deeply exploiting all functionalities of fewer components provides a facile but effective solution for cancer treatments, demonstrating great therapeutic and industrial potentials.