文献类型：期刊文献

英文题名：The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering

作者：Li, Yulin[1];Xiao, Yin[2];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia

年份：2017

卷号：117

期号：5

起止页码：4376

外文期刊名：CHEMICAL REVIEWS

收录：;EI(收录号：20171003429318);WOS:【SCI-EXPANDED(收录号:WOS:000396185400010)】；

基金：We are grateful for the financial support from the Key Program of the National Natural Science Foundation of China (31330028) and the Shanghai Municipal Natural Science Foundation (15ZR1408500). Shanghai International Cooperation Program (15520711100) and 111 Project (B14018) is also acknowledged for financial support. We greatly thank Suzanne Squires (New Jersey Center for Biomaterials, Rutgers University) for her help in polishing the manuscript.

语种：英文

外文关键词：Cell adhesion - Cell engineering - Biological systems - Bioactivity - Stem cells - Biomaterials - Biomechanics - Tissue regeneration

摘要：Although the biological functions of cell and tissue can be regulated by biochemical factors (e.g., growth factors, hormones), the biophysical effects of materials on the regulation of biological activity are receiving more attention. In this Review, we systematically summarize the recent progress on how biomaterials with controllable properties (e.g., compositional/degradable dynamics, mechanical properties, 2D topography, and 3D geometry) can regulate cell behaviors (e.g., cell adhesion, spreading, proliferation, cell alignment, and the differentiation or self-maintenance of stem cells) and tissue/organ functions. How the biophysical features of materials influence tissue/organ regeneration have been elucidated. Current challenges and a perspective on the development of novel materials that can modulate specific biological functions are discussed. The interdependent relationship between biomaterials and biology leads us to propose the concept of "materiobiology", which is a scientific discipline that studies the biological effects of the properties of biomaterials on biological functions at cell, tissue, organ, and the whole organism levels. This Review highlights that it is more important to develop ECM-mimicking biomaterials having a self-regenerative capacity to stimulate tissue regeneration, instead of attempting to recreate the complexity of living tissues or tissue constructs ex vivo. The principles of materiobiology may benefit the development of novel biomaterials providing combinative bioactive cues to activate the migration of stem cells from endogenous reservoirs (i.e., cell niches), stimulate robust and scalable self-healing mechanisms, and unlock the body's innate powers of regeneration.