文献类型：期刊文献

英文题名：Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides

作者：Guo, Ying[1];Fan, Xue-Min[1];Nie, Min[1];Liu, Hong-Wei[1];Liao, Dao-Hua[1];Pan, Xian-Dao[2,3];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China

年份：2015

卷号：2015

期号：21

起止页码：4744

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000358217200024)，CCR-EXPANDED(收录号:WOS:000358217200024)】；

基金：The authors are grateful to the National Natural Science Foundation of China (NSFC) (project numbers 21176074 and 21476074) and the Research Fund for the Doctoral Program of Higher Education of China (project number 20130074110009) for financial support.

语种：英文

外文关键词：Homogeneous catalysis; Copper; Alkoxylation; Aromatic substitution

摘要：An efficient and practical short-chain alkoxylation of unactivated aryl bromides has been developed with special attention focussed on the applicability of the reaction. Sodium alkoxide is used as the nucleophile, and the corresponding alcohol as the solvent. The reaction requires neither precious metals nor organic ligands. It uses a catalytic system consisting of copper(I) bromide as a catalyst, the corresponding alkyl formate as a noncontaminating cocatalyst, and lithium chloride as an additive. A wide range of substrates and test cases highlight the synthetic utility of the approach. Considering the commercial accessibility and affordability of the feedstocks, this protocol shows promise as a new alternative for the sustainable preparation of aryl alkyl ethers.