文献类型：期刊文献

英文题名：Dynamic supramolecular hydrogels mediated by chemical reactions

作者：Chen, Jingjing[1];Wang, Hucheng[1];Long, Feng[1];Bai, Shengyu[1];Wang, Yiming[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：59

期号：96

起止页码：14236

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20234715075365);WOS:【SCI-EXPANDED(收录号:WOS:001101860300001)】；

基金：We acknowledge the financial support of the Shanghai Pilot Program for Basic Research (grant no. 22TQ1400100-9), the "Chenguang Program" supported by the Shanghai Education Development Foundation and Shanghai Municipal Education Commission (grant no. 20CG36), the Natural Science Foundation of Shanghai (grant no. 22ZR1417700), the National Key Research and Development Program of China (grant no. 2022YFD70050101), the Open Project of State Key Laboratory of Chemical Engineering (grant no. SKL-ChE23C01), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Hydrogels - Indicators (chemical) - Molecular biology - Supramolecular chemistry

摘要：Supramolecular self-assembly in a biological system is usually dominated by sophisticated metabolic processes (chemical reactions) such as catalysis of enzymes and consumption of high energy chemicals, leading to groups of biomolecules with unique dynamics and functions in an aqueous environment. In recent years, increasing efforts have been made to couple chemical reactions to molecular self-assembly, with the aim of creating supramolecular materials with lifelike properties and functions. In this feature article, after summarising the work of chemical reaction mediated supramolecular hydrogels, we first focus on a typical example where dynamic self-assembly of molecular hydrogels is activated by in situ formation of a hydrazone bond in water. We discuss how the formation of the hydrazone-based supramolecular hydrogels can be controlled in time and space. After that, we describe transient assembly of supramolecular hydrogels powered by out-of-equilibrium chemical reaction networks regulated by chemical fuels, which show unique properties such as finite lifetime, dynamic structures, and regenerative capabilities. Finally, we provide a perspective on the future investigations that need to be done urgently, which range from fundamental research to real-life applications of dynamic supramolecular hydrogels. This Feature Article summarizes the recent advances in the chemical reaction mediated supramolecular hydrogels and provides perspectives for further advances.