文献类型：期刊文献

英文题名：Edwardsiella piscicida: A versatile emerging pathogen of fish

作者：Leung, Ka Yin[1];Wang, Qiyao[2,3,4];Yang, Zhiyun[1];Siame, Bupe A.[5]

机构：[1]Guangdong Technion Israel Inst Technol, Biotechnol & Food Engn, Shantou, Guangdong, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Engn Res Ctr Marine Cultured Anim Vaccin, Shanghai, Peoples R China;[4]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Shanghai, Peoples R China;[5]Trinity Western Univ, Dept Biol, Langley, BC, Canada

年份：2019

卷号：10

期号：1

起止页码：555

外文期刊名：VIRULENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000473787100002)】；

基金：This work was supported by the National Natural Science Foundation of China [#31873048]; Ministry of Agriculture of China [CARS-47]; Science and Technology Commission of Shandong and Shanghai Municipality [2017CXGC0103 and 17391902000]; National Key R&D Program of China [2018YFD0900504].

语种：英文

外文关键词：Edwardsiella piscicida; T3SS/T6SS and effectors; intracellular and systemic infection; resistome; virulence mechanisms

摘要：Edwardsiella piscicida is an Enterobacteriaceae that is abundant in water and causes food and waterborne infections in fish, animals, and humans. The bacterium causes Edwardsiellosis in farmed fish and can lead to severe economic losses in aquaculture worldwide. E. piscicida is an intracellular pathogen that can also cause systemic infection. Type III and type VI secretion systems are the bacterium's most lethal weapons against host defenses. It also possesses multiantibiotic resistant genes and is selected and enriched in the environment due to the overuse of antibiotics. Therefore, the bacterium has great potential to contribute to the evolution of the resistome. All these properties have made this bacterium a perfect model to study bacteria virulence mechanisms and the spread of antimicrobial genes in the environment. We summarize recent advance in E. piscicida biology and provide insights into future research in virulence mechanisms, vaccine development and novel therapeutics.