文献类型：期刊文献

中文题名：双激发驱动的全组分响应镧系金属-有机骨架用于多 元疾病标志物的双模式检测

英文题名：A dual-excitation-driven full-component-responsive lanthanide-based metal-organic framework for switchable profiling of multi-disease markers

作者：Chen, Guoli[1];Dai, Bin[2];Hao, Ji-Na[1];Li, Yongsheng[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ,Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn,Lab Low Dimens Mat Chem,Key Lab, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Peoples R China

年份：2025

卷号：68

期号：2

起止页码：666

外文期刊名：SCIENCE CHINA-MATERIALS

收录：;EI(收录号：20251218062448);WOS:【SCI-EXPANDED(收录号:WOS:001395451700001)】；

基金：This work was supported by the National Key Research and Development Program of China (2022YFC2403203, 2024YFF0508601), the National Natural Science Foundation of China (52172279), the Basic Research Program of Shanghai (21JC1406003), the Shanghai Rising-Star Program (21QA1402200), the Leading Talents in Shanghai in 2018, the Key Field Research Program (2023AB054), and the Higher Education Discipline Innovation Project (B14018).

语种：中文

外文关键词：luminescent probes; lanthanide-based metal-organic frameworks; dual-excitation regulation; multi-disease markers detection

摘要：Accurate detection of multiple small end-metabolic biomarkers is more sensitive than large biomolecules to provide real-time feedbacks of physiological/pathological state, but is more challenging due to lack of specific identifying groups. Current optical platforms suffer from unsatisfactory resolutions to differentiate each target because they produce similar output to different targets using a single excitation, and inevitably involve non-functional components that increase chances of interacting with non-target molecules. Herein, by taking full advantage of each building unit's functionality to integrate multivariate recognition elements in one interface, a dual-excitation-driven full-component-responsive metal-organic framework (MOF)-based luminescent probe, namely CeTMA-TMA-Eu, is successfully custom-tailored for detecting both pseudouridine (psi) and N-acetylaspartate (NAA), the diagnostic hallmarks of cancer and neurodegenerative disorder. Remarkably, psi interacts with MOF's organic building unit (trimesic acid, TMA) and filters out its absorptions of 262 nm-light to reduce its energy transferred to Eu3+, while NAA induces the valence transition of Ce4+/Ce3+ nodes to improve the cooperative energy transfer efficacy from TMA and Ce3+ to Eu3+. As a result, this platform exhibits completely reverse photoresponses towards psi ("switch-off" at 262 nm excitation) and NAA ("switch-on" upon 296 nm excitation), and demonstrates excellent selectivity and sensitivity in complex biofluids, with low detection limits of 0.16 and 0.15 mu M, and wide linear ranges of 0-180 and 0-100 mu M, respectively. Such full-component-responsive probe with dual-excitation-mediated reverse responses for multi-small targets intrinsically minimizes its interaction with non-target molecules and amplifies resolution to discriminate each target, providing a new strategy for improving assay accuracy of multi-small biomarkers in diagnostics. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic),(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (sic). (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). (sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)MOFs(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (sic),(sic)(sic)(sic)(sic)(sic)(sic)MOF(sic)(sic)(sic)(sic)(CeTMA-TMA-Eu), (sic)(sic)(sic)262(sic) 296 nm(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(Psi, (sic)TMA(sic)(sic)(sic)(sic)(sic)(sic) 262 nm(sic)(sic)(sic))(sic)N-(sic)(sic)(sic)(sic)(sic)(sic)(NAA, (sic)(sic)Ce4+(sic)(sic)(sic)(sic)(sic)(sic))(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)0.16(sic)0.15 mu M, (sic)(sic)(sic)(sic)(sic)(sic) (sic)0-180(sic)0-100 mu M. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).