文献类型：期刊文献

英文题名：Construction of indazolo[3,2-a]isoquinolines via [3+2] cycloaddition of benzynes

作者：Li, Yue-Kun[1];Cui, Ming-Xin[1];Sha, Feng[1];Li, Qiong[1];Wu, Xin-Yan[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：17

期号：40

起止页码：8963

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20194307576778);WOS:【SCI-EXPANDED(收录号:WOS:000490731400003)，CCR-EXPANDED(收录号:WOS:000490731400003)】；

基金：We are grateful for financial support from the Shanghai Pujiang Program (18PJD010), the Natural Science Foundation of Shanghai (19ZR1412300), and the Fundamental Research Funds for the Central Universities (222201814019).

语种：英文

外文关键词：Scaffolds - Scaffolds (biology)

摘要：A [3 + 2] annulation protocol for the construction of N-substituted indazolo[3,2-a]isoquinolines starting from benzynes and C,N-cyclic azomethine imines was developed. A diverse range of highly functionalized products indazolo[3,2-a]isoquinolines featuring an indazole scaffold can be easily accessed via a one-step reaction under mild conditions, and they show good anti-proliferative activity on cancer cells.