文献类型：期刊文献

英文题名：Highly Regio-, Diastereo-, and Enantioselective Assembly of Azepino[2,3-b]indoles via Palladium-Catalyzed [4+3] Cycloaddition

作者：Yang, Wu-Lin[1,2];Huang, Zesheng[1,2];Liu, Yang-Zi[1,2];Yu, Xingxin[1,2];Deng, Wei-Ping[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Zhejiang Normal Univ, Dept Chem, Key Lab, Minist Educ Adv Catalysis Mat, Jinhua 321004, Zhejiang, Peoples R China

年份：2020

卷号：38

期号：12

起止页码：1571

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000572169300001)，CCR-EXPANDED(收录号:WOS:000572169300001)】；

基金：This work is supported by the National Natural Science Foundation of China (Nos. 21772038, 21971062, and 21901072), and Shanghai Sailing Program (No. 18YF140560).

语种：英文

外文关键词：Asymmetric catalysis; Palladium; [4+3] Cycloaddition; Trimethylenemethane; Azepino[2,3-b]indole; Synthetic method

摘要：A Summary of main observation and conclusion A palladium-catalyzed asymmetric [4 + 3] cycloaddition of trimethylenemethanes and indoline-derived aza-dienes has been developed. The potential [3 + 2] side pathway was completely suppressed in the process. This protocol provides an efficient access to azepino[2,3-b]indoles bearing two vicinal stereocenters in generally excellent diastereo- and enantioselectivities (up to > 20 : 1 dr, 99% ee).