文献类型：期刊文献

英文题名：Chemical signal regulated injectable coacervate hydrogels

作者：Wu, Bohang[1,2];Lewis, Reece W. W.[2];Li, Guotai[2];Gao, Yifan[1];Fan, Bowen[2];Klemm, Benjamin[2];Huang, Jianan[1];Wang, Junyou[1];Cohen Stuart, Martien A. A.[1];Eelkema, Rienk[2]

机构：[1]East China Univ Sci & Technol, Dept Chem Engn, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]Delft Univ Technol, Dept Chem Engn, Van der Maasweg 9, NL-2629 HZ Delft, Netherlands

年份：2023

卷号：14

期号：6

起止页码：1512

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20230513460725);WOS:【SCI-EXPANDED(收录号:WOS:000915304400001)】；

基金：Financial support by the China Scholarship Council (B. W., the State Scholarship Fund File No. 202006740035) and the European Research Council (R. E., ERC consolidator grant 726381) is acknowledged. We thank Prof. Stephen Picken (TU Delft) for inspiring discussions on rheological measurements as well as Ruben Boot (TU Delft) for provision and assistance with NIH-3T3 cell line. We thank Jinbo Liu (ECUST) for assistance with photographing.

语种：英文

外文关键词：Addition reactions - Degradation - Gelation - Organometallics - Sol-gels

摘要：In the quest for stimuli-responsive materials with specific, controllable functions, coacervate hydrogels have become a promising candidate, featuring sensitive responsiveness to environmental signals enabling control over sol-gel transitions. However, conventional coacervation-based materials are regulated by relatively non-specific signals, such as temperature, pH or salt concentration, which limits their possible applications. In this work, we constructed a coacervate hydrogel with a Michael addition-based chemical reaction network (CRN) as a platform, where the state of coacervate materials can be easily tuned by specific chemical signals. We designed a pyridine-based ABA triblock copolymer, whose quaternization can be regulated by an allyl acetate electrophile and an amine nucleophile, leading to gel construction and collapse in the presence of polyanions. Our coacervate gels showed not only highly tunable stiffness and gelation times, but excellent self-healing ability and injectability with different sized needles, and accelerated degradation resulting from chemical signal-induced coacervation disruption. This work is expected to be a first step in the realization of a new class of signal-responsive injectable materials.