文献类型：期刊文献

英文题名：A microporous surface containing Si3N4/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration

作者：Hu, Xinglong[1];Mei, Shiqi[1];Wang, Fan[1];Tang, Songchao[1];Xie, Dong[2];Ding, Chao[1];Du, Wenli[1];Zhao, Jun[3];Yang, Lili[2];Wu, Zhaoying[4];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Shanghai Changzheng Hosp, Spine Ctr, Dept Orthopaed, Shanghai 200003, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9,Dept Orthodont, Shanghai Key Lab Stomatol,Shanghai Res Inst Stoma, Shanghai 200011, Peoples R China;[4]Sun Yat Sen Univ, Sch Biomed Engn, Guangzhou 510006, Guangdong, Peoples R China

年份：2021

卷号：6

期号：10

起止页码：3136

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000672673500010)】；

基金：The grants were supported by the National Natural Science Foundation of China (81771990, 81801845 and 81200815), Key Medical Program of Science and Technology Development of Shanghai (19441906100 and 17441902000) and Shenzhen Fundamental Research Program (JCYJ20190807160811355).

语种：英文

外文关键词：Silicon nitride; Tantalum; Polyetherketoneketone; Antibacterial activity; Osseointegration

摘要：As an implantable biomaterial, polyetherketoneketone (PEKK) exhibits good mechanical strength but it is biologically inert while tantalum (Ta) possesses outstanding osteogenic bioactivity but has a high density and elastic modulus. Also, silicon nitride (SN) has osteogenic and antibacterial activity. In this study, a microporous surface containing both SN and Ta microparticles on PEKK (STP) exhibiting excellent osteogenic and antibacterial activity was created by sulfonation. Compared with sulfonated PEKK (SPK) without microparticles, the surface properties (roughness, surface energy, hydrophilicity and protein adsorption) of STP significantly increased due to the SN and Ta particles presence on the microporous surface. In addition, STP also exhibited outstanding antibacterial activity, which inhibited bacterial growth in vitro and prevented bacterial infection in vivo because of the presence of SN particles. Moreover, the microporous surface of STP containing both SN and Ta particles remarkably induced response (e.g., proliferation and differentiation) of rat bone mesenchymal stem (rBMS) cells in vitro. Furthermore, STP significantly improved new bone regeneration and osseointegration in vivo. Regarding the induction of cellular response in vitro and improvement of osseointegration in vivo, the microporous surface containing Ta was better than the surface with SN particles. In conclusion, STP with optimized surface properties activated cellular responses in vitro, enhanced osseointegration and prevented infection in vivo. Therefore, STP possessed the dual biofunctions of excellent osteogenic and antibacterial activity, showing great potential as a bone substitute.