文献类型：期刊文献

中文题名：氯虫酰胺的合成

英文题名：Synthesis of chlorantraniliprole

作者：陈一芬[1];刘爱霞[1];冀亚飞[1]

机构：[1]华东理工大学药学院,上海200237

年份：2010

卷号：32

期号：10

起止页码：937

中文期刊名：化学试剂

外文期刊名：Chemical Reagents

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：氯虫酰胺;杀虫剂;鱼尼丁受体;合成

外文关键词：chlorantraniliprole; insecticide; ryanodine receptor; synthesis

摘要：以3-甲基-2-硝基苯甲酸为原料,经酯化、还原、氯化、氨解制得关键中间体2-氨基-5-氯-N,3-二甲基苯甲酰胺。中间体与3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸发生酰胺化反应制得标题化合物,总收率55.0%。其结构经1HNMR和MS确证。
3-Methyl-2-nitrobenzoic acid was used as the starting material to undergo a series of reactions including esterification,reduction,chlorination and aminolysis to give the key intermediate 2-amino-5-chloro-N,3-dimethylbenzamide.The intermediate was amidated with 3-bromo-1-（3-chloro-2-pyridinyl）-1H-pyrazole-5-carboxylic acid to provide the target product in an overall yield of 55.0%.The product structure was confirmed by 1HNMR and MS.