文献类型：期刊文献

中文题名：接枝型聚两性电解质 CS-g-PLGA 的合成及溶液性质

英文题名：Synthesis and Solution Properties of CS-g-PLGA Graft Polyampholytes

作者：魏照骏[1];陈叶[1];王冬梅[2];房文祥[1];陈涛[1];章苏宁[3]

机构：[1]华东理工大学材料科学与工程学院上海市先进聚合物材料重点实验室,上海200237;[2]大连熹霖科技股份有限公司,大连116023;[3]上海应用技术学院香料香精技术与工程学院,上海200235

年份：2014

卷号：35

期号：6

起止页码：1348

中文期刊名：高等学校化学学报

外文期刊名：Chemical Journal of Chinese Universities

收录：CSTPCD;;EI(收录号：20142817935968);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000338273200035)】；北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：Supported by the National Natural Science Foundation of China (No. 20974032).

语种：中文

中文关键词：聚两性电解质;接枝共聚物;壳聚糖;聚(L-谷氨酸);环境敏感性

外文关键词：Polyampholyte;Graft copolymer;Chitosan;Poly（L-glutamic acid）;Stimuli-responsive property

摘要：合成了以壳聚糖(CS)为主链、聚(L-谷氨酸)(PLGA)为侧链的接枝型聚两性电解质CS-g-PLGA(CGA),表征了其结构与组成,探讨了pH值、离子强度和离子种类等对CGA水溶液性质的影响.研究发现,随着溶液离子强度的增大,CGA的等电点(IEP)移向高pH值;离子水化半径越大,对CGA分子中相反电荷的屏蔽作用越弱,对IEP的影响越小;CGA中氨基和羧基相对含量越接近,对溶液离子强度的变化越敏感.此外,CGA具有显著的pH响应性,在酸性及碱性溶液中分别形成结构相反的聚集体.在CS主链氨基含量相近的条件下,聚集体的稳定性随PLGA链长的增加而提高.酸性溶液中聚集体粒径取决于CS主链的电荷数;碱性溶液中PLGA侧链越长则平均粒径越大.
The graft polyampholytes containing a chitosan backbone and poly（ L-glutamic acid） branches, i. e. CS-g-PLGA（CGA）, with different compositions were synthesized. The molecular architecture and the composition of CGA were characterized. The influences of environmental conditions, such as pH value, ionic strength and ionic types, on the aqueous solution properties of CGAs were investigated. The results show that the isoelectric point（IEP） of CGA shifts to higher pH values with increasing the ionic strength. The larger the ion hydration radius is, the less it influences the IEP. The CGA with approximative amino and carboxyl con-tents is more sensitive to the variation of ionic strength. Moreover, CGAs exhibit notable pH responsibility to form reversible aggregates in acidic and alkaline solutions, respectively. The stability of the aggregates is found to be improved by increasing the length of PLGA branches for CGAs with similar amino content. The hydrody-namic radii of the aggregates depend on the charge density on CS backbone in acidic solutions and increase with increasing PLGA length in alkaline solutions.