文献类型：期刊文献

英文题名：Effect of coordination sphere of the copper center and Cu-Cu distance on catechol oxidase and nuclease activities of the copper complexes

作者：Zheng, Bin[1];Liu, Hui[1];Feng, Jie[1];Zhang, Jingyan[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：28

期号：5

起止页码：372

外文期刊名：APPLIED ORGANOMETALLIC CHEMISTRY

收录：;EI(收录号：20141817670670);WOS:【SCI-EXPANDED(收录号:WOS:000334780700010)】；

基金：The authors gratefully acknowledge the financial support of the National Natural Science Foundation (Nos. 31070742 and 21001044), the State Key Laboratory of Bioreactor Engineering (No. 2060204) and the Shanghai Committee of Science and Technology (No. 11DZ2260600).

语种：英文

外文关键词：copper complexes; catechol oxidase; nuclease; intermetallic distance; coordination sphere

摘要：To explore the effect of Cu?Cu distance in the structure of copper complexes on their catechol oxidase and nuclease activity, six copper complexes with a similar coordination sphere but different Cu?Cu distances were synthesized and characterized with elemental analysis, single-crystal X-ray diffraction, molar conductivity measurements, IR and UV-visible spectroscopy. Complex 1 is a binuclear copper complex and complex 4 is a polynuclear complex with a Z-chain structure, as evidenced by their crystal structures. Complementary characterizations showed that complexes 2 and 3 have a similar binuclear structure to the complex 1; and complexes 5 and 6 are analogous to complex 4. The catechol oxidase activity of complexes 1, 2, 3 is quite akin to that of 4, 5, 6, suggesting that the catechol oxidase activity of the complexes was determined by the coordination environment of the copper center, when Cu?Cu distance is large. In contrast, DNA cleavage activity of the complexes 1, 2 and 3 are much higher than that of 4, 5 and 6, indicating that the planar ligand structure in the complexes 4, 5 and 6 is more critical than the copper coordination sphere and the Cu?Cu distance for their nuclease activity. Copyright (c) 2014 John Wiley & Sons, Ltd.