文献类型：期刊文献

英文题名：Benzoic Acid Catalyzed Annulations of α-Amino Acids and Aromatic Aldehydes Containing an ortho-Michael Acceptor: Access to 2,5-Dihydro-1H-benzo[c]azepines and 10,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a]azepines

作者：Tang, Mi;Tong, Lingfeng;Ju, Lei;Zhai, Wanwan;Hu, Yang;Yu, Xinhong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, State Key Lab Bioengn Reactors, Shanghai 200237, Peoples R China

年份：2015

卷号：17

期号：21

起止页码：5180

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000364434900009)，CCR-EXPANDED(收录号:WOS:000364434900009)】；

基金：We gratefully acknowledge financial support from the National Nature Science Foundation of China (20972051 and 21476078, X.-H.Y.; 08431901800 and 08430703900, X.-H.Y.). We thank Professor Dr. Youjun Yang (East China University of Science & Technology) and Professor Dr. Wei Wang (University of New Mexico) for helpful discussions.

语种：英文

摘要：A novel one-pot efficient synthesis of 2,5-dihydro-1H-benzo[c]azepines and 10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a]azepines from alpha-amino acids and aromatic aldehydes containing an ortho-Michael acceptor is reported via decarboxylative annulations without metal catalysts in yields of 52-91%. Under microwave irradiation, this protocol provides rapid access to polycyclic ring systems (only 5 min in most cases).