文献类型：期刊文献

英文题名：Novel poly(ε-caprolactone)s bearing amino groups: Synthesis, characterization and biotinylation

作者：Yan, Jinliang[1];Zhang, Yi[1];Xiao, Yan[1];Zhang, Yan[1];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2010

卷号：70

期号：7

起止页码：400

外文期刊名：REACTIVE & FUNCTIONAL POLYMERS

收录：;EI(收录号：20103213127168);WOS:【SCI-EXPANDED(收录号:WOS:000279038200002)】；

基金：This research was supported by the Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (No. 20674019, 20804015), "Shu Guang" Project of Shanghai Municipal Education Commission, Specialized Research Fund for the Doctoral Program of Higher Education (200802511021), the Natural Science Foundation of Shanghai (08ZR1406000), Shanghai Leading Academic Discipline Project (B502) and Shanghai Key Laboratory Project (08DZ2230500).

语种：英文

外文关键词：gamma-(Carbamic acid benzyl ester)-epsilon-caprolactone; Ring-opening polymerization; Poly(epsilon-caprolactone); Baeyer-Villiger reaction; Amino groups; Biotinylation

摘要：A novel functional E-caprolactone monomer containing protected amino groups, gamma-(carbamic acid benzyl ester)-epsilon-caprolactone (gamma CAB epsilon CL), was successfully synthesized. A series of copolymers [poly(CL-co-CAB CL)] were prepared by ring-opening polymerization of epsilon-caprolactone (CL) and gamma CABECL in bulk using tin (II)-2-ethylhexanoate [Sn(Oct)(2)] as catalyst. The morphology of the copolymers changed from semi-crystalline to amorphous with increasing gamma CABECL monomer content. They were further converted into deprotected copolymers [poly(CL-co-ACL)] with free amino groups by hydrogenolysis in the presence of Pd/C. After deprotection, the free amino groups on the copolymer were further modified with biotin. The monomer and the corresponding copolymers were characterized by H-1 NMR, C-13 NMR, FT-IR, mass, GPC and DSC analysis. The obtained data have confirmed the desired monomer and copolymer structures. (C) 2010 Elsevier Ltd. All rights reserved.