文献类型：期刊文献

英文题名：Assembly of a Highly Stable Luminescent Zn5 Cluster and Application to Bio-Imaging

作者：Zeng, Ming-Hua[1,2];Yin, Zheng[3];Liu, Ze-Hui[4];Xu, Hai-Bing[1,2];Feng, Ying-Chun[1,2];Hu, Yue-Qiao[1,2];Chang, Li-Xian[1,2];Zhang, Yue-Xing[1,2];Huang, Jin[4];Kurmoo, Mohamedally[5]

机构：[1]Guangxi Normal Univ, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China;[2]Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Peoples R China;[3]Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Xian 710021, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[5]Univ Strasbourg, Inst Chim Strasbourg, CNRS, UMR 7177, 4 Rue Blaise Pascal, F-67070 Strasbourg, France

年份：2016

卷号：55

期号：38

起止页码：11407

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20163402722318);WOS:【SCI-EXPANDED(收录号:WOS:000383748900013)】；

基金：This work was supported by the National Science Foundation of China for Distinguished Young Scholars (No. 21525101), the NSFC (No. 91422302, 21371037, and 21571165), the NSFGX (No. 2014GXNSFFA118003, CMEMR2014-A02), BAGUI scholar program (2014A001) and the Project of Talents Highland of Guangxi province. M.K. thanks the CNRS-France.

语种：英文

外文关键词：3d-metal coordination cluster; bio-imaging; fluorescence probes; pH sensitivity; Zn clusters

摘要：The assembly sequence of the coordination cluster [Zn-5(H2Ln)(6)](NO3)(4)]8H(2)O2CH(3)OH (Zn-5, H3Ln=(1,2-bis(benzo[d]imidazol-2-yl)-ethenol) involves insitu dehydration of 1,2-bis(benzo[d]imidazol-2-yl)-1,2-ethanediol (H4L) through the formation of the [Zn(H3L)(2)](+) monomer, dimerization to [Zn-2(H3L)(2)](+), dehydration of the ligand to [Zn-2(H2Ln)(2)](+), and the final formation of the pentanuclear cluster. The cluster has the following special characteristics: 1) high stability in both refluxing 37% HCl and 27% NH3, 2) low cytotoxicity, and 3) pH-sensitive fluorescence in the visible-to-near-infrared (Vis/NIR) region in the solid state and in solution. We have applied it as a fluorescent probe both in vivo and invitro. Its H-bonding ability is the key to its affinity and selectivity for imaging lysosomes in HeLa cells and tumors in male BALB/C mice. It provides a new type of sensitive and biocompatible fluorescent probe for detecting small tumors (13.5mm(3)).