文献类型：期刊文献

英文题名：Unexpected strong paramagnetism of hydrogels containing carbon-oxygen double bonds induced by calcium cations

作者：Chen, Ruoyang[1];Zhang, Yue-Yu[2,3,4];Huang, Xing[2,5];Wang, Liping[2];Zhang, Lei[6];Song, Chao[6];Dai, Lixiong[2];Zhang, Min[1,2];Wang, Jun[1];Jian, Yong[2];Xu, Weiyuan[2];Dong, Hui[7,8];Peng, Bingquan[2];He, Shuqiang[1];Liang, Shanshan[1];Dai, Fangfang[2];Fan, Qihui[9];Ye, Fangfu[2,9,10];Zhang, Xin[6];Zhang, Feng[2,11];Fang, Haiping[1,2,12]

机构：[1]East China Univ Sci & Technol, Sch Phys, Shanghai Key Lab Atom Control & Applicat Inorgan S, Shanghai, Peoples R China;[2]Univ Chinese Acad Sci, Wenzhou Inst, Beijing, Zhejiang, Peoples R China;[3]East China Normal Univ, Sch Phys & Elect Sci, Key Lab Polar Mat & Devices MOE, Shanghai, Peoples R China;[4]East China Normal Univ, Shanghai Ctr Brain inspired Intelligent Mat & Devi, Shanghai, Peoples R China;[5]Hangzhou City Univ, Zhejiang Prov Engn Ctr Integrated Mfg Technol & In, Sch Engn, Hangzhou, Zhejiang, Peoples R China;[6]Chinese Acad Sci, Hefei Inst Phys Sci, CAS High Magnet Field Lab CHMFL, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China;[7]Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Natl Key Lab Mat Integrated Circuits, Shanghai, Peoples R China;[8]Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Shanghai Key Lab Supercond Integrated Circuit Tech, Shanghai, Peoples R China;[9]Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing, Peoples R China;[10]Zhejiang Lab Regenerat Med Vision & Brain Hlth, Oujiang Lab, Wenzhou, Zhejiang, Peoples R China;[11]Univ Shanghai Sci & Technol, Terahertz Technol Innovat Res Inst, Terahertz Spectrum & Imaging Technol Cooperat Inno, Sch Opt Elect & Comp Engn,Shanghai Key Lab Modern, Shanghai, Peoples R China;[12]Zhejiang Univ, Inst Adv Study Phys, Sch Phys, Hangzhou, Zhejiang, Peoples R China

年份：2026

卷号：25

期号：5

外文期刊名：NATURE MATERIALS

收录：;EI(收录号：20260520001271);WOS:【SCI-EXPANDED(收录号:WOS:001672657900001)】；

基金：We thank Y. Gao, Q. Chen, P. Xiu, J. Farrell, L. Zhang, X. Lei, Y. Huang and H. He for constructive suggestions, and Y. Li and J. Lian for their assistance with the experiments. We also thank the staff from BL07U beamline of Shanghai Synchrotron Radiation Facility (SSRF) for assistance with the XANES data collection. H.F. acknowledges the NSFC (grant number 12435001), Shanghai Science and Technology Innovation Action Plan (grant number 23JC1401400) and Fundamental Research Funds for the Central Universities of East China University of Science. R.C. acknowledges the Shanghai Pujiang Program (grant number 23PJ1401800). X.Z. acknowledges the NSFC (grant number U21A20148) and CAS Project for Young Scientists in Basic Research (YSBR-097). Y.Z. acknowledges the NSFC (grant number 12404265). X.H. acknowledges the NSFC (grant number 52303304). F.Y. acknowledges the NSFC (grant numbers 12325405 and T2221001). F.Z. acknowledges the NSFC (grant numbers 32271298 and T2241002), the National Key Research and Development Program of China (2021YFA1200402) and the University of Chinese Academy of Sciences (WIUCASQD2021003). L.W. acknowledges the University of Chinese Academy of Sciences (WIUCASQD2021011). L.Z. acknowledges the NSFC (grant number 52377228). Q.F. acknowledges the NSFC (grant number 12422408).

语种：英文

外文关键词：Additives - Alginate - Calcium - Carbon - Drug delivery - Hydrogels - Magnetic moments - Magnetic resonance imaging - Medical applications - Paramagnetism - Sodium compounds

摘要：Hydrogels do not have observable responses to external magnetic fields as they are conventionally thought to be diamagnetic. These materials require additives for magnetic control, limiting biomedical applications due to potential side effects. Here we show that calcium cations can induce strong paramagnetism of hydrogels rich in groups containing carbon-oxygen double bonds, including alginate, carboxymethyl chitosan, polyacrylamide and N-isopropyl acrylamide. Both experiments and computations reveal that the ubiquitous presence of net magnetic moments, the key to paramagnetism, is induced by the unexpected coupling of a single calcium cation and one carbonyl group under large calcium cation excess conditions. The paramagnetic phenomenon is also observed in the endogenous biomolecule sodium hyaluronate with calcium cations. We further demonstrate the applications of the strongly paramagnetic alginate-calcium hydrogel as a contrast agent in magnetic resonance imaging and a carrier in magnetic drug delivery. Our findings provide insights into the origin of magnetism and advance magnetism-related biomedical innovations.