文献类型：期刊文献

英文题名：Kinetic Resolution of α-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer Catalyst An-PIQ

作者：Jiang, Shan-Shan[1];Xu, Qin-Chang[1];Zhu, Ming-Yu[1];Yu, Xingxin[1];Deng, Wei-Ping[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2015

卷号：80

期号：6

起止页码：3159

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20151300679644);WOS:【SCI-EXPANDED(收录号:WOS:000351558400021)，CCR-EXPANDED(收录号:WOS:000351558400021)】；

基金：We are grateful for financial support from the Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (no. 21372074).

语种：英文

外文关键词：Esters

摘要：A highly efficient nonenzymatic kinetic resolution of a series of structurally diverse racemic alpha-methylene-beta-hydroxy esters utilizing the acyl transfer catalyst An-PIQ and propionic anhydride is reported. This procedure provides recovered alcohols with extremely high ees (up to >99%) in reasonable conversions and excellent selectivity factors (S up to 108). Several synthetically important substrates were resolved in gram-scale reactions, and highly optically pure alpha-methylene-beta-hydroxy esters were obtained with excellent S values and good yields.