文献类型：期刊文献

英文题名：Controlled copolymerization of α-NCAs and α-NNTAs for preparing peptide/peptoid hybrid polymers with adjustable proteolysis

作者：Zou, Jingcheng[1];Zhou, Min[1];Ji, Zhemin[2];Xiao, Ximian[2];Wu, Yueming[2];Cui, Ruxin[2];Deng, Shuai[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me, Res Ctr Biomed Mat,Minist Educ,Key Lab Ultrafine, Shanghai 200237, Peoples R China

年份：2022

卷号：13

期号：3

起止页码：388

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20220611586519);WOS:【SCI-EXPANDED(收录号:WOS:000730275000001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 22075078, 21774031, 21861162010, 31800801), the Program of Shanghai Academic/Technology Research Leader (20XD1421400), the Research Program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (JKD01211520). We also thank the Research Center of Analysis and Test of East China University of Science and Technology for the help with the characterization. We also thank the staff members of the Mass Spectrometry System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab, China for providing technical support and assistance in data collection and analysis.

语种：英文

外文关键词：Amino acids - Biocompatibility - Copolymerization - Proteolysis - Synthesis (chemical)

摘要：Peptides and polypeptides have excellent biocompatibility and numerous biological functions; however, their application is restricted by their proneness to proteolytic degradation. Although the incorporation of peptoid residues into peptides can improve their stability against proteases, the synthesis of peptide/peptoid hybrid oligomers suffers from the tedious and time consuming solid-phase synthesis process. Hereby, we report a living and controlled copolymerization of alpha-amino acid N-carboxyanhydrides (alpha-NCAs) and N-substituted alpha-amino acid N-thiocarboxyanhydrides (alpha-NNTAs) for the facile synthesis of peptide/peptoid hybrid polymers with an alternating-like distribution of residues, controllable molecular weight and narrow dispersity. Moreover, this polymerization strategy enables quick synthesis of peptide mimicking peptide/peptoid hybrid polymers with adjustable proteolysis by varying the proportion of peptoid residues. Our studies shed some light on the facile synthesis of peptide mimicking peptide/peptoid hybrid polymers with tunable proteolysis and open new avenues for preparing novel peptide mimics with tunable proteolysis and large structural diversity.