文献类型：期刊文献

英文题名：Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

作者：Jin, Tongxia[1,3];Cheng, Di[1];Jiang, Guanyu[2];Xing, Wenqian[1,3];Liu, Peiwen[1,3];Wang, Bin[1];Zhu, Weiping[1,3];Sun, Haitao[2];Sun, Zhenrong[2];Xu, Yufang[1];Qian, Xuhong[1,3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Phys & Elect Sci, State Key Lab Precis Spect, 500 Dongchuan Rd, Shanghai 200241, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：14

起止页码：42

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000788639700001)】；

基金：This work was supported by National Natural Science Foundation of China (Grants 21878088, 12034008, 21476077, 11727810) , Key pro-jects of Shanghai Science and Technology Commission (18DZ1112703) , and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28)

语种：英文

外文关键词：Near-infrared dye; Integration strategy; Phototherapy; Combination therapy; Drug delivery system

摘要：Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye ML880 with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with IR820. Furthermore, ML880 is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica (RMON) to construct nanomedicine NBD&ML@RMON, which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.