文献类型：期刊文献

中文题名：磺化羟丙基壳聚糖凝胶选择吸附血液低密度脂蛋白

英文题名：Study on the Selective Adsorption of Low-density -Lipoprotein by Hydroxylpropyl Chitosangel Sulfate

作者：方波[1];江体乾[1]

机构：[1]华东理工大学化学工程研究所

年份：1998

卷号：24

期号：2

起止页码：134

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：1998074298455);Scopus;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金

语种：中文

中文关键词：壳聚糖;磺化;凝胶;吸附;脂蛋白;血液;净化

外文关键词：chitosan; chitosan sulfated derivatives; heparinlike materials; low-density lipoproteins; blood purification; plasmapheresis

摘要：研究了文题物质的性能，考察了磺化程度对脂蛋白吸附效果的影响。结果表明，磺化羟丙基壳聚糖凝胶具有良好的选择吸附性能，是一种新型低密度脂蛋白吸附剂。可使血浆总胆固醇下降３５％～６０％，低密度脂蛋白和极低密度脂蛋白下降６０％～９０％，而高密度脂蛋白无显著变化。干基吸附容量约为４～９ｍｇ／ｇ（胆固醇／干胶），且干基吸附容量随磺化程度的提高而增大。
The selective adsorption of lowdensity lipoproteins (LDL) by hydroxylpropyl chitosangel sulfate (HPCSSGel) was studied. The effect of the extent of sulfation on the LDLadsorption was investigated. Experimental results showed that, HPCSSGel possessed good property for the selective adsorption of LDL, and it′s a novel LDLadsorbent. The reduction percentages were about 35%￣60% for total cholesterol, about 60%￣90% for LDL and very lowdensity lipoproteins. There was no significant changes for the level of highdensity lipoproteins. The adsorption capacity based on dry resin was from 4-9mg/g(cholesterol/dry resin), and it was improved with the increment of the extent of sulfation of HPCSSGel.